V. Rubtsov, Candidate of Medical Sciences; E. Fedotov, Candidate of Medical
Sciences; «Medical Di Center» LLC, Engels
Objective. To develop a method for quantitative determination of carcinoembryonic antigen (CEA) content in endophytic cancer tissues and colon mucosa and to assess the possibility of practical application of the obtained data.
Materials and methods. The study material included biopsies of endophytic cancer tumors and mucosa taken during colonoscopy from 16 patients with colorectal cancer and 18 control group patients aged 36 to 72 years. Quantitative determination of CEA content was performed in biopsy homogenates using an modified method using immunochemiluminescent analysis on an automatic analyzer.
Results. The data obtained indicate a significantly higher CEA content in cancer tumor tissues compared to the surrounding mucous membrane and can serve as a basis for laboratory differential diagnostics of colorectal carcinomas with rapid and slow growth rates, including interval cancers.
For citation: Rubtsov V., Fedotov E. Quantitative content of carcinoembryonic antigen in endophytic colorectal cancer tumors and colon mucosa. Vrach. 2025; 36 (12): 36–39. https://doi.org/10.29296/25877305-2025-12-07
About the authors: Rubtsov V.S. ORCID: 0009-0007-3209-4426